The benchmark in beauty-from-within has always been measurable efficacy. Now, VeCollal® sets a new one.

A peer-reviewed clinical study by the University of Pavia (Italy) has tested VeCollal®, a plant-based, biomimetic collagen alternative, in a rigorous double-blind, placebo-controlled design. The goal: quantify changes in skin condition after 8 weeks of daily 5g supplementation.

Here’s what the science shows:

🔬 +21.16% skin hydration

Skin hydration was measured via Corneometer. After 8 weeks:

• VeCollal® group: +21.16% improvement
• Placebo group: –0.26%

🔬 +10.5% dermal collagen signal

Using DermaLab Combo ultrasound, the study recorded a 10.5% increase in collagen signal intensity for VeCollal®. This indicates real changes in structural skin composition, not just surface-level effects.

🔬 –20.10% visible cellulite volume

Cellulite affects over 85% of women and remains one of the most persistent formulation challenges.

• Hydration

• Collagen density

• Cellulite

It’s a clean-label, animal-free ingredient with clinical validation — ready to answer growing consumer demand and regulatory pressure for sustainable innovation.

For years, the collagen industry had a simple, unchallenged formula: animal input equals skin output. Whether it came from bovine hides, fish scales or chicken sternums, collagen supplementation meant consuming animal by-products — often in high daily doses, and with questionable efficacy. Vegan options? None. Not serious ones, anyway.

That era is ending.

A new category is emerging, backed by science and driven by changing consumer values. Plant-based collagen alternatives — once seen as a nice story with no scientific leg to stand on — are finally delivering hard clinical proof. And the implications are massive.

The problem with the old model

Consumers today expect more. They want efficacy, yes. But they also care about sustainability, transparency, inclusivity, and ethical sourcing. The traditional collagen market doesn’t meet those expectations. Animal-based collagen peptides rely on waste streams from the meat and fishing industries. They raise questions about origin, allergens, religious suitability, and ecological footprint.

And then there’s the dose. 10 to 20 grams per day is standard for most animal collagen products. That’s a lot of powder to mix, and a lot of cost to carry — for results that, while promising, often lack strong clinical consistency.

Until now, vegan brands had little to offer in return. Most “plant-based collagen” products on the market were vague blends of vitamins, botanicals or collagen-boosting claims. None actually mimicked real human collagen. None had proven wrinkle, hydration or skin structure benefits. And none had strong clinical backing.

The science that changes everything

That has now changed. VeCollal® is the world’s first scientifically validated, biomimetic, plant-based collagen alternative. It replicates the amino acid profile of human collagen using entirely vegan ingredients. And it has now been clinically proven — in two separate university-led studies — to visibly improve the three biggest skin concerns:VeCollal® is the world’s first scientifically validated, biomimetic, plant-based collagen alternative. It replicates the amino acid profile of human collagen using entirely vegan ingredients. And it has now been clinically proven — in two separate university-led studies — to visibly improve the three biggest skin concerns:

• Wrinkles

• Hydration

• Cellulite

The most recent trial was conducted by Etichub in collaboration with the University of Pavia (Italy) and followed gold-standard protocols: randomized, double-blind, placebo-controlled. Over 56 days, 60 healthy women aged 39–65 took either 5 grams of VeCollal® Type I daily or a placebo.

The results were conclusive — and measured instrumentally using 3D imaging, ultrasound and corneometry:

• 20.10% reduction in cellulite appearance

• 21.16% increase in skin hydration

• 10.5% increase in dermal collagen intensity

That’s not marketing spin. That’s hard data. And it comes at a daily dose of just 5 grams — half or less of what’s typical for animal collagen.

Two studies, one conclusion

These new results follow an earlier clinical trial conducted in Taiwan and published in the Journal of Functional Foods. That first study showed:

• 32.9% reduction in average wrinkle depth

• 6% increase in skin elasticity

• 7.7% increase in skin density

• 13.1% improvement of skin texture

Together, both studies show a clear pattern: VeCollal® doesn’t just offer a plant-based alternative — it offers clinically proven performance across the full spectrum of skin aging.VeCollal® doesn’t just offer a plant-based alternative — it offers clinically proven performance across the full spectrum of skin aging.

The next generation of collagen

VeCollal® is vegan and halal certified, kosher suitable, non-GMO and allergen-free. It enables brands to meet the growing demand for cleaner, inclusive, science-backed products — without sacrificing performance.

For years, collagen has been synonymous with bovine hides and fish scales. Even today, most formulations on the market still rely on animal-derived ingredients — despite rising concerns around ethics, sustainability, consumer acceptance, and sourcing volatility.

One reason for the industry’s slow shift was the assumption that nothing else could match animal collagen’s performance. That belief is now outdated.

With the recent conclusion of an independent, double-blind clinical trial by the University of Pavia (Italy), VeCollal® has become the first plant-based collagen alternative to be scientifically validated across multiple visible skin concerns. In just 8 weeks, and with only 5g/day:

• Cellulite appearance reduced by 20.10%

• Skin hydration improved by 21.16%

• Collagen intensity increased by 10.5%

These findings build on an earlier peer-reviewed human study, published in the Journal of Functional Foods, that showed significant improvements in wrinkle depth, elasticity, and density.

Together, the results demonstrate that collagen alternatives are no longer a nice idea. They're a credible, effective solution — backed by science, not just storytelling.

And they bring other benefits with them: cruelty-free, vegan, non-GMO, halal-certified, kosher-suitable, allergen-free, and compatible with clean-label claims.

For beauty and wellness brands, the question isn’t just “can we match animal collagen?” It’s “why are we still depending on it?”

The science is here. The shift is real. And VeCollal® is ready to power the next generation of skincare and joint health supplements.